Factors Associated With Disease Recurrence in Breast Cancer Patients With Negative Sentinel Lymph Node Biopsy

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• 作者：Elena Navarro-Rodrí ; guez¹ ; ^{helenanr1@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; Né ; lida Dí ; az-Jimé ; nez¹ ; Juan Ruiz-Rabelo¹ ; Irene Gó ; mez-Luque¹ ; Guillermo Bascuñ ; ana-Estudillo¹ ; Pilar Rioja-Torres¹ ; Manuela Torres-Lorite¹ ; Rubé ; n Ciria-Bru¹ ; Marina Á ; lvarez-Benito² ; Javier Briceñ ; o-Delgado¹
• 关键词：Breast cancer ; Disease recurrence ; Metastases ; Negative lymph nodes ; Sentinel node
• 刊名：Clinical Breast Cancer
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：16
• 期：6
• 页码：e181-e186
• 全文大小：248 K

文摘

The objective of our study was to assess recurrence after negative sentinel lymph node biopsy (SLNB) and to determine the risk factors related to local and distant recurrence in this group of patients.

Materials and Methods

We conducted a prospective observational study from 2006 to 2011. It included 607 patients with early-stage breast cancer and negative SLNB with a 5-year follow-up period.

Results

The disease-free survival rate was 98.5% and 96.5% at 2 and 5 years, respectively. Multivariate analysis identified the following prognostic factors for disease recurrence: tumor necrosis (hazard ratio [HR], 4.89; 95% confidence interval [CI], 1.61-14.89; P = .005), lymphovascular invasion (HR, 3.46; 95% CI, 1.14-10.55; P = .029), T2 tumor size (HR, 4.35; 95% CI, 1.40-13.52; P = .011), and moderate to severe lymphoplasmacytic stromal infiltration (HR, 3.06; 95% CI, 1.18-7.96; P = .022).

Conclusion

Recurrence in patients with negative SLNB was satisfactorily low. Nevertheless, determining the prognostic factors related to a greater recurrence rate could help identify high-risk patients and influence systemic adjuvant therapy.