In vitro metabolism of phenytoin in 36 CYP2C9 variants found in the Chinese population
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- 作者：Lian-Guo Chena ; 1 ; Zhe Wangb ; 1 ; Yuan Zhua ; Jian-Hua Xionga ; Li-Rong Suna ; Da-Peng Daic ; Jian-Ping Caic ; caijp61@vip.sina.com" class="auth_mail" title="E-mail the corresponding author ; Guo-Xin Hud ; wzhhgx@aliyun.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Phenytoin ; CYP2C9 ; Allelic variant ; Chinese population ; Catalytic activity ; In vitro
- 刊名：Chemico-Biological Interactions
- 出版年：2016
- 出版时间：25 June 2016
- 年：2016
- 卷：253
- 期：Complete
- 页码：93-99
- 全文大小：762 K
文摘
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We recently identified 22 novel CYP2C9 alleles in the Han Chinese population.
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We assess the catalytic activities of 36 CYP2C9 alleles variants toward phenytoin in vitro.
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There are 17 variants showed decreased catalytic activity toward phenytoin.