A rapid and sensitive UHPLC-MS/MS assay for the determination of trelagliptin in rat plasma and its application to a pharmacokinetic study
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- 作者：Xiao-xia Hu ; Tian Lan ; Zhe Chen ; Cheng-cheng Yang ; Peng-fei Tang ; Ling-jing Yuan ; Guo-Xin Hu ; hgx@wmu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Jian-Ping Cai ; caijp61@vip.sina.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Trelagliptin ; UHPLC&ndash ; MS/MS ; Pharmacokinetics ; Rat plasma
- 刊名：Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences
- 出版年：2016
- 出版时间：15 October 2016
- 年：2016
- 卷：1033-1034
- 期：Complete
- 页码：166-171
- 全文大小：779 K
文摘
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It is the first time to report the determination of trelagliptin in rat plasma.
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This UHPLC–MS/MS method is simple, rapid and sensitive.
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The method has been successfully applied to pharmacokinetic.
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The absolute bioavailability of trelagliptin was reported as high as 57.3%.