- 作者：Pablo Moreno ; Aitor de la Quintana Basarrate ; Thomas J. Musholt ; Ivan Paunovic ; Marco Puccini ; 脫scar Vidal ; Joaqu铆n Ortega ; Jean-Louis Kraimps ; Elisabet Bollo Arocena ; Jos茅 M. Rodr铆guez ; 脫scar Gonz谩lez L贸pez ; Carlos D. del Pozo ; Maurizio Iacobone ; Enrique Veloso ; Jos茅 M. del Pino ; I帽igo Garc铆a Sanz ; David Scott-Coombes ; Jes煤s Villar-del-Moral ; Jos茅 I. Rodr铆guez ; Jaime V谩zquez Echarri ; et al.
- 刊名：Surgery
- 出版年：December, 2013
- 年：2013
- 卷：154
- 期：6
- 页码：1215-1223
- 全文大小：255 K
ass="h4">Background
We assessed the results of adrenalectomy for solid tumor metastases in 317 patients recruited from 30 European centers.ass="h4">Methods
Patients with histologically proven adrenal metastatic disease and undergoing complete removal(s) of the affected gland(s) were eligible.
ass="h4">Results
Non-small cell lung cancer (NSCLC) was the most frequent tumor type followed by colorectal and renal cell carcinoma. Adrenal metastases were synchronous (鈮? months) in 73 (23%) patients and isolated in 213 (67%). The median disease-free interval was 18.5 months. Laparoscopic resection was used in 46% of patients. Surgery was limited to the adrenal gland in 73% of patients and R0 resection was achieved in 86% of cases. The median overall survival was 29 months (95% confidence interval, 24.69-33.30). The survival rates at 1, 2, 3, and 5 years were 80%, 61%, 42%, and 35%, respectively. Patients with renal cancer showed a median survival of 84 months, patients with NSCLC 26 months, and patients with colorectal cancer 29 months (P = .017). Differences in survival between metachronous and synchronous lesions were also significant (30 vs 23 months; P = .038).
ass="h4">Conclusion
Surgical removal of adrenal metastasis is associated with long-term survival in selected patients.