Cigarette smoke extracts induce overexpression of the proto-oncogenic gene interleukin-13 receptor α2 through activation of the PKA-CREB signaling pathway to trigger malignant transformation of lung vascular endothelial cells and angiogenesis
Cigarette smoke extracts induce overexpression of pro-tumorigenic IL-13Rα2 gene. CSEs induce IL-13Rα2 overexpression by activation of the PKA-CREB signaling axis. IL-13Rα triggers malignant transformation of ECs and promotes tumor angiogenesis.