A novel spermatogenesis-specific uPAR gene expressed in human and mouse testis

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• 作者：Xiaokun Teng ; Jun Yang ; Yong Xie ; Zumei Ni ; Ruiying Hu ; Lvjie Shi ; Zhixin Lin ; Landian Hu ; Guoping Zhao ; Xiaoyan Ding and Xiangying Kong
• 关键词：Urokinase receptor ; Spermatogenesis ; Testis ; Scleroderma ; Peripheral leukocytes
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2006
• 出版时间：21 April 2006
• 年：2006
• 卷：342
• 期：4
• 页码：1223-1227
• 全文大小：406 K

文摘

The urokinase receptor, uPAR, which binds to the urinary-type plasminogen activator, controls matrix degradation in the processes of tissue remodeling, cell migration, and invasion. In the present study, we found a new urokinase receptor gene that encodes a 249-amino acid putative protein. Northern blot analysis showed specific expression in the testis of this gene, which we named the spermatogenesis-related gene (SGRG). In situ hybridization revealed a strong expression signal for SGRG in spermatogonia, but not in spermatocytes. Therefore, we conjecture that SGRG may regulate spermatocyte migration through breakdown of extracellular matrix protein barriers in spermatogenesis. Since SGRG is specifically expressed in spermatogonia, it provides an attractive candidate for development of a contraceptive vaccine.