Platelet function one and three months after coronary bypass surgery in relation to once or twice daily dosing of acetylsalicylic acid

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• 作者：Torbjö ; rn Ivert^a ; ^{torbjorn.ivert@ki.se} ; Magnus Dalé ; n^a ; Charlotte Ander^b ; Ragnhild Stå ; lesen^b ; Per Nä ; sman^c ; Marie Lordkipanidzé ; ^d ; Paul Hjemdahl^b
• 关键词：Aspirin ; Coronary artery bypass grafting ; Individualized therapy ; Platelet function ; Thromboxane
• 刊名：Thrombosis Research
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：149
• 期：Complete
• 页码：64-69
• 全文大小：455 K
• 卷排序：149

文摘

Platelet activation was enhanced one and three months after CABG. ASA 160 mg OD and 75 mg BID most effectively suppressed thromboxane production. Platelet aggregation was least effectively inhibited by ASA 75 mg OD. ASA higher than 75 mg OD should be considered the first 3 months after CABG. Twice daily dosing of ASA is of interest for further evaluation.