MiR-509-3-5p causes aberrant mitosis and anti-proliferative effect by suppression of PLK1 in human lung cancer A549 cells
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- 作者：Xian-Hui Wanga ; 1 ; Yao Lua ; 1 ; Jing-Jing Lianga ; Ji-Xiang Caoa ; Ya-Qiong Jinb ; Guo-Shun Ana ; Ju-Hua Nia ; Hong-Ti Jiaa ; Shu-Yan Lia ; shuyanli@bjmu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：miR-509-3-5p ; PLK1 ; Aberrant mitosis ; Cisplatin ; Adriamycin ; DNA damage response
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：16 September 2016
- 年：2016
- 卷：478
- 期：2
- 页码：676-682
- 全文大小：1304 K
文摘
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MiR-509-3-5p represses PLK1 expression by targeting PLK1 3ʹ-UTR.
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Expression of miR-509-3-5p is induced and PLK1 repressed upon DNA damage.
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Overexpression of miR-509-3-5p induces G2/M arrest and aberrant mitosis.
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MiR-509-3-5p inhibits cell proliferation and sensitizes cells to DNA damage agents.