Phospho-Pon Binding-Mediated Fine-Tuning of Plk1 Activity
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- 作者：Kang Zhu1 ; 3 ; Zelin Shan1 ; 3 ; Lu Zhang1 ; 3 ; Wenyu Wen1 ; 2 ; wywen@fudan.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 刊名：Structure
- 出版年：2016
- 出版时间：6 July 2016
- 年：2016
- 卷：24
- 期：7
- 页码：1110-1119
- 全文大小：2575 K
文摘
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Cdk1 phosphorylates Pon at Thr63, thus creating a Plk1 PBD binding site
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Phospho-Pon binding induces PBD dimerization, thus relieving Plk1 autoinhibition
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Binding to different phosphoproteins has a distinct effect on Plk1 activity
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Cdk1 and Polo/Plk1 sequentially phosphorylate Pon