Polo-like Kinase-1 Regulates Myc Stabilization and Activates a Feedforward Circuit Promoting Tumor Cell Survival
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- 作者：Daibiao Xiao1 ; 2 ; Ming Yue2 ; Hexiu Su2 ; Ping Ren2 ; Jue Jiang2 ; Feng Li3 ; Yufeng Hu2 ; Haining Du3 ; Hudan Liu1 ; 2 ; Guoliang Qing1 ; 2 ; 4 ; qingguoliang@whu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Myc ; PLK1 ; Fbw7 ; ubiquitination ; neuroblastoma ; small cell lung carcinoma ; BI6727 ; ABT199 ; targeted therapy
- 刊名：Molecular Cell
- 出版年：2016
- 出版时间：3 November 2016
- 年：2016
- 卷：64
- 期：3
- 页码：493-506
- 全文大小：3739 K
文摘
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PLK1 is essential for stabilizing Myc family oncoproteins
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PLK1 promotes Fbw7 phosphorylation, autopolyubiquitination, and degradation
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N-Myc directly activates PLK1 transcription
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Combined inhibition of PLK1 and Bcl2 represent potential Myc-targeting therapeutics