Formulation of cyclodextrin inclusion complex-based orally disintegrating tablet of eslicarbazepine acetate for improved oral bioavailability
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- 作者：Samixa Desai ; Aditi Poddar ; Krutika Sawant ; dr_krutikasawant@yahoo.co.in" class="auth_mail" title="E-mail the corresponding author
- 关键词：Eslicarbazepine acetate ; 尾-cyclodextrin ; Solid dispersion ; Orally disintegrating tablets ; Bioavailability
- 刊名：Materials Science & Engineering C
- 出版年：2016
- 出版时间：1 January 2016
- 年：2016
- 卷：58
- 期：Complete
- 页码：826-834
- 全文大小：732 K
文摘
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尾-cyclodextrin–eslicarbazepine acetate complex developed with enhanced solubility.
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Formulated Orally disintegrating tablets (ODT) disintegrated within 30 s.
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Bioavailability from ODT was 2 times higher than marketed tablets.
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Onset of action for ODT was also faster than marketed tablets.
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Formulated ODT would aid epileptic patients incapable of swallowing tablets.