The comparison of dextranomer/hyaluronic acid and polyacrylate-polyalcohol copolymers in endoscopic treatment of vesicoureteral reflux

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• 作者：Suleyman Cuneyt Karakus^a ; ^{sckarakus@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; İdil Rana User^a ; Beltinge Demircioglu Kılıc^b ; Vedat Akç ; aer^a ; Haluk Ceylan^a ; Bulent Hayri Ozokutan^a
• 关键词：Vesicoureteral reflux ; Dextranomer ; Polyacrylate-polyalcohol ; STING ; Double HIT
• 刊名：Journal of Pediatric Surgery
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：51
• 期：9
• 页码：1496-1500
• 全文大小：646 K

文摘

Dextranomer/hyaluronic acid (Dx/Ha;Dexell®) and polyacrylate-polyalcohol copolymer (PPC;Vantris®) are the popular tissue-augmenting substances using for the endoscopic injections of vesicoureteral reflux (VUR). The aim of the study is to evaluate and compare Dx/Ha and PPC in terms of effectiveness, injection techniques and complications with special emphasis on vesicoureteral junction obstruction (VUJO).

Methods

A total of 95 patients who underwent endoscopic VUR treatment between 2009 and 2015 were retrospectively reviewed. The patients were divided into two groups: group 1: Patients underwent endoscopic treatment with PPC (n = 50 patients, 70 renal refluxing units) group 2: Patients underwent endoscopic treatment with Dx/Ha (n = 45 patients, 74 renal refluxing units).

Results

The overall resolution rates based on the number of renal refluxing units studied was 88.6% and 70.3% in group 1 and group 2, respectively. Resolution rates were significantly better in group 1 compared to group 2. VUJO requiring ureteral reimplantation or stent insertion developed in 7 patients in group 1. No VUJO was observed in group 2. VUJO in group 1 was markedly higher than that in group 2.

Conclusions

Endoscopic treatment of VUR with PPC promises better resolution rates but higher VUJO rates compared to Dx/Ha.