Mitochondrial poly(ADP-ribose) polymerase: The Wizard of Oz at work
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- 作者：Attila Brunyanszkia ; Bartosz Szczesnya ; b ; Lá ; szló ; Virá ; gc ; Csaba Szaboa ; b ; szabocsaba@aol.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：AIF ; apoptosis-inducing factor ; ARH3 ; ADP-ribosyl protein hydrolase-3 ; ART ; ADP-ribosyl transferase ; BER ; base excision repair ; EXOG ; endo/exonuclease (5&prime ; &minus ; 3&prime ; ) ; endonuclease G-like ; grp75 ; 75 ; kDa glucose regulated protein ; ligIII ; DNA ligase 3 MOMP ; mitochondrial outer membrane permeabilization ; MPT ; mitochondrial permeability transition pore ; mtDNA ; mitochondrial DNA ; mtPARP ; mitochondrial poly(ADP-ribose) polymerase ; mPTP ; mitochondrial permeability transition pore comple
- 刊名：Free Radical Biology and Medicine
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：100
- 期：Complete
- 页码：257-270
- 全文大小：3417 K
文摘
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Although PARP1's actions have been most commonly studied in the nucleus, several lines of data demonstrate that PARP1 is also present in the mitochondria.
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Mitochondrial PARP1 plays an important role in the regulation of various cellular functions in health and disease.
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The current article reviews the experimental evidence for the mitochondrial localization of PARP1 and its intra-mitochondrial functions, with focus on cellular bioenergetics, mitochondrial DNA repair and mitochondrial dysfunction.
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In addition, we also propose a working model for the interaction of mitochondrial and nuclear PARP during oxidant-induced cell death.