Crystal structure of Deep Vent DNA polymerase

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• 作者：Yasushi Hikida^a ; ^b ; ^c ; Michiko Kimoto^a ; ^d ; ^e ; Ichiro Hirao^a ; ^d ; ^e ; ^{ichiro@ibn.a-star.edu.sg} ; Shigeyuki Yokoyama^a ; ^b ; ^c ; ^{yokoyama@riken.jp}
• 关键词：DNA polymerase ; Unnatural base pair ; X-ray crystallography ; Polymerase chain reaction
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：29 January 2017
• 年：2017
• 卷：483
• 期：1
• 页码：52-57
• 全文大小：1983 K
• 卷排序：483

文摘

The crystal structure of Deep Vent DNA polymerase was determined. The structure explains the specificities of DNA polymerases for unnatural base pairs. The structure will contribute to the development of mutants for more unnatural bases.