Tracking HCV protease population diversity during transmission and susceptibility of founder populations to antiviral therapy

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• 作者：Tanvi Khera^a ; Daniel Todt^a ; Koen Vercauteren^b ; C. Patrick McClure^c ; Lieven Verhoye^b ; Ali Farhoudi^b ; Sabin Bhuju^d ; Robert Geffers^d ; Thomas F. Baumert^e ; ^f ; ^g ; Eike Steinmann^a ; Philip Meuleman^b ; Thomas Pietschmann^a ; ^h ; Richard J.P. Brown^a ; ^{richard.brown@twincore.de}
• 关键词：HCV protease ; Transmission ; Founder populations ; Longitudinal evolution ; RAS emergence
• 刊名：Antiviral Research
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：139
• 期：Complete
• 页码：129-137
• 全文大小：2534 K
• 卷排序：139

文摘

Single-source HCV outbreak modeled in vivo using chimeric human-liver mice and tracked via NGS. Genetic bottleneck and strong purifying selection shape viral populations at transmission. Founder populations evolve along different trajectories post transmission. Founder populations susceptible to antiviral monotherapy. Complex patterns of RAS emergence with unique signatures in individual mice.