Sedation mediates part of Citalopram's effect on agitation in Alzheimer's disease
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- 作者：Jeffery Newella ; Jerome A. Yesavageb ; c ; d ; yesavage@stanford.edu" class="auth_mail" title="E-mail the corresponding author ; Joy L. Taylorb ; c ; Helena C. Kraemerc ; Cynthia A. Munroe ; Leah Friedmanc ; Paul B. Rosenberge ; Michelle Madoreb ; c ; Steven Z. Chaob ; d ; D.P. Devanandf ; g ; Lea T. Dryeh ; Jacobo E. Mintzeri ; j ; Bruce G. Pollockk ; Anton P. Porsteinssonl ; Lon S. Schneiderm ; David M. Shadeh ; Daniel Weintraubn ; o ; Constantine G. Lyketsose ; Art Nodac ; for the CitAD Research Group
- 关键词：Agitation ; Sedation ; Citalopram
- 刊名：Journal of Psychiatric Research
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：74
- 期：Complete
- 页码：17-21
- 全文大小：448 K
文摘
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Clinical trial found benefit of citalopram for agitation in Alzheimer's disease.
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We examined if effect of treatment drug on agitation was mediated by its sedating effect.
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We found that benefit of citalopram was mediated by a significant but small sedative effect.
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Other unknown factors explain majority of effects of Citalopram on agitation.