Cell Competition Drives the Growth of Intestinal Adenomas in Drosophila
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- 作者：Saskia J.E. Suijkerbuijk1 ; 2 ; Golnar Kolahgar1 ; Iwo Kucinski1 ; Eugenia Piddini1 ; e.piddini@gurdon.cam.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：cancer ; tumor microenvironment ; cell competition ; adenomatous polyposis coli (APC) ; Drosophila ; posterior midgut ; cell death ; apoptosis ; JNK signaling ; Hippo signaling ; Yki/YAP/TAZ ; intestinal adenomas
- 刊名：Current Biology
- 出版年：2016
- 出版时间：22 February 2016
- 年：2016
- 卷：26
- 期：4
- 页码：428-438
- 全文大小：7956 K
文摘
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In the fly gut APC−/− tumors kill surrounding cells and cause loss of healthy tissue
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Tumor-host cell competition fuels tumor growth
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JNK signaling boosts APC−/− adenoma growth and drives cell competition
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Differences in Yki activity determine the cell competition potential of APC−/− cells