Two essential peritrophic matrix proteins mediate matrix barrier functions in the insect midgut
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- 作者：Sinu Agrawala ; 1 ; Marco Kelkenbergb ; 1 ; Khurshida Begumc ; Lea Steinfeldb ; Clay E. Williamsa ; Karl J. Kramera ; d ; Richard W. Beemand ; Yoonseong Parkc ; Subbaratnam Muthukrishnana ; smk@ksu.edu" class="auth_mail ; Hans Merzendorferb ; merzendorfer@biologie.uni-osnabrueck.de" class="auth_mail
- 关键词：Dextrans ; Chitin ; Insect ; Fat body ; Midgut ; Peritrophic matrix proteins ; Permeability ; Red flour beetle ; RNA interference ; Tribolium castaneum
- 刊名：Insect Biochemistry and Molecular Biology
- 出版年：June 2014
- 年：2014
- 卷：49
- 期：Complete
- 页码：24-34
- 全文大小：2445 K
文摘
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We examined putative peritrophic matrix proteins (PMPs) from Tribolium castaneum.
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The PMP genes are differentially expressed along the length of the midgut.
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PM permeability decreases from the anterior to the posterior midgut.
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RNAi for two essential PMP genes leads to starvation and developmental defects.
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These PMP genes are crucial for the maintenance of the PM's barrier function.