Activation of 5-HT2A/2C receptors reduces the excitability of cultured cortical neurons
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- 作者：Lingli Hua ; b ; Chunhua Liua ; b ; Minyan Danga ; b ; Bin Luoc ; Yiping Guoa ; b ; guo_yiping@gibh.ac.cn" class="auth_mail" title="E-mail the corresponding author ; Haitao Wanga ; b ; d ; wang_haitao@gibh.ac.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：5-HT ; 5-hydroxytryptamine ; ATP ; adenosine-5&prime ; -triposphate ; DIV ; days in vitro ; DOI ; 2 ; 5-dimethoxy-4-iodoamphetamine ; EGTA ; ethyleneglykole-bis-(2-aminoethyl)-tetraacetic acid ; GABA ; gamma-aminobutyric ; GTP ; guanosine-5&prime ; -triphosphate ; HCN ; hyperpolarization-activated cyclic nucleotide-gated ; HEPES ; N-2-hydroxyethylpiperaxine-N-2-ethanesulfonic acid ; mEPSCs ; miniature excitatory postsynaptic currents ; mIPSCs ; miniature inhibitory postsynaptic currents ; TTX ; tetrodoxin
- 刊名：Neuroscience Letters
- 出版年：2016
- 出版时间：6 October 2016
- 年：2016
- 卷：632
- 期：Complete
- 页码：124-129
- 全文大小：1238 K
文摘
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DOI depresses spontaneous firing of cortical neurons, mimicking the effect of serotonin.
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DOI depresses current-evoked firing and increases neuronal input resistance.
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HCN channels account for DOI-induced increase of input resistance, but not for the decrease of spontaneous firing.
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DOI differentially affects mEPSCs and mIPSCs.