Effects of memantine on the excitation-inhibition balance in prefrontal cortex
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- 作者：Nadezhda V. Povyshevaa ; nvp1@pitt.edu" class="auth_mail" title="E-mail the corresponding author ; Jon W. Johnsona ; b ; jjohnson@pitt.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：AD ; Alzheimer's disease ; NMDAR ; N-methyl-d-aspartate receptor ; AMPAR ; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors ; E/I ; excitation/inhibition ; EGFP ; enhanced green fluorescent protein ; PFC ; prefrontal cortex ; sEPSCs ; spontaneous excitatory postsynaptic currents ; sIPSCs ; spontaneous inhibitory postsynaptic currents ; mIPSC ; miniature inhibitory postsynaptic currents ; dIPSCs ; disynaptic inhibitory postsynaptic currents ; moEPSCs ; monosynaptic excitatory postsynaptic currents ; PV
- 刊名：Neurobiology of Disease
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：96
- 期：Complete
- 页码：75-83
- 全文大小：1540 K
文摘
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Novel actions of the Alzheimer's Disease (AD) drug memantine were investigated.
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Memantine disinhibits cortex by shifting excitation/inhibition balance.
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Memantine reduces NMDAR responses in PV + interneurons more than in pyramidal neurons.
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Memantine reduces spiking in PV + interneurons, increases spiking in pyramidal neurons.
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Disinhibition may be an effective mechanism of action for new AD therapeutics.