Regulation of mismatch repair by histone code and posttranslational modifications in eukaryotic cells
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- 作者：Feng Lia ; Janice Ortegab ; Liya Gub ; Guo-Min Lib ; c ; guominli@usc.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：MMR ; mismatch repair ; MSI ; microsatellite instability ; PCNA ; proliferating cellular nuclear antigen ; RPA ; replication protein A ; RFC ; replication factor C ; EXO1 ; exonuclease 1 ; H3K36me3 ; histone H3 lysine 36 trimethylation
- 刊名：DNA Repair
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：38
- 期：Complete
- 页码：68-74
- 全文大小：339 K
文摘
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Histone mark H3K36me3 is required for mismatch repair in vivo.
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PCNA phosphorylation promotes genome instability by inhibiting mismatch repair.
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MSH2 deacetylation/ubiquitination by HDAC6 downregulates mismatch repair activity.