The molecular mechanism behind reactive aldehyde action on transmembrane translocations of proton and potassium ions
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- 作者：Olga Jovanovica ; Alina A. Pashkovskayaa ; Andrea Annibalb ; Mario Vazdarc ; Nadine Burchardta ; Anna Sansoned ; Lars Gillee ; Maria Fedorovab ; Carla Ferrerid ; Elena E. Pohla ; elena.pohl@vetmeduni.ac.at" class="auth_mail" title="E-mail the corresponding author
- 关键词：RA ; reactive aldehydes ; ONE ; 4-oxo-2-nonenal ; HNE ; 4-hydroxy-2-nonenal ; HHE ; 4-hydroxy-2-hexenal ; UCP1 ; uncoupling protein 1 ; CCCP ; carbonyl cyanide m-chlorophenyl hydrazine ; AA ; arachidonic acid ; DHA ; docosahexaenoic acid ; EPA ; eicosapentanoic acid ; ROS ; reactive oxygen species ; FA ; long chain fatty acid ; DOPE ; 1 ; 2-Dioleoyl-sn-glycero-3-phosphoethanolamine ; DOPC ; 1 ; 2-dioleoyl-sn-glycero-3-phosphocholine ; CL ; cardiolipin ; PG ; phosphatidylglycerol ; DPPC ; 1 ; 2-dihexadecanoyl-sn-glycero-3-phosphocho
- 刊名：Free Radical Biology and Medicine
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：89
- 期：Complete
- 页码：1067-1076
- 全文大小：2638 K
文摘
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HNE, ONE and HHE form different adducts with phosphatidylethanolamine (PE).
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Adducts increase the activity of membrane transporters (UCP1, valinomycin).
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Molecular mechanism includes membrane fluidity and energy barrier alteration.
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This mechanism is proposed to be common for all membrane proteins.