刊名:Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
出版年:2017
出版时间:January 2017
年:2017
卷:1863
期:1
页码:310-323
全文大小:1610 K
卷排序:1863
文摘
TPPP/p25 is co-enriched and co-localized with SYN in brain inclusions of Parkinson’s disease patients. Interaction of SYN with various deletion mutants and fragments of TPPP/p25 were characterized. Chameleon feature of TPPP/p25 has been established at molecular and cellular level as well as by bioinformatics’ approach. New innovative strategy is based upon the targeting of the interface of TPPP/p25 complexed with SYN but not with tubulin.