文摘
The APP/PS1 mouse is an animal model of Alzheimer's disease. Aβ plaques are seen at 6–7 months in APP/PS1 mice but not at 2 months. Spatial learning and memory is impaired in APP/PS1 mice at 8–9 months. In contrast, peripheral glucose regulation is altered by 2 months in APP/PS1 mice. Thus, a pre-diabetic phenotype precedes classical AD-related pathology.