Association of calcineurin A gamma subunit (PPP3CC) and early growth response 3 (EGR3) gene polymorphisms with susceptibility to schizophrenia in a Japanese population

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• 作者：Chieko Kyogoku ; Masaya Yanagi ; Kunihiro Nishimura ; Daisuke Sugiyama ; Akio Morinobu ; Masaaki Fukutake ; Kiyoshi Maeda ; Osamu Shirakawa ; Takayoshi Kuno ; Shunichi Kumagai
• 关键词：Schizophrenia ; Calcineurin A gamma subunit (PPP3CC) ; Early growth response 3 (EGR3)
• 刊名：Psychiatry Research
• 出版年：2011
• 出版时间：30 January 2011
• 年：2011
• 卷：185
• 期：1-2
• 页码：16-19
• 全文大小：355 K

文摘

To examine the association of PPP3CC (rs10108011 and rs2461491) and EGR3 (rs3750192) single-nucleotide polymorphisms (SNPs) with Japanese schizophrenia, we performed a case–control association study using 337 patients and 369 healthy controls. As a result, by our moderated cohort-size study, PPP3CC and EGR3 are not genetic risk factors for schizophrenia, whereas meta-analysis showed weak association of rs10108011 with schizophrenia in the Japanese population (odds ratio (OR) = 1.12, P = 0.01).