Agmatine attenuates neuropathic pain in sciatic nerve ligated rats: Modulation by hippocampal sigma receptors

详细信息    查看全文

• 作者：N ; kishor Ramdas Kotagale ; Saurabh Haridas Shirbhate ; Pradeep Shukla ; Rajesh Ramesh Ugale
• 关键词：Agmatine ; Allodynia ; Hyperalgesia ; Neuropathic pain ; Sigma Receptor ; Hippocampus ; TNF-¦Á
• 刊名：European Journal of Pharmacology
• 出版年：2013
• 出版时间：15 August, 2013
• 年：2013
• 卷：714
• 期：1-3
• 页码：424-431
• 全文大小：1809 K

文摘

Present study investigated the influence of the sigma (¦Ò₁ and ¦Ò₂) receptors within hippocampus on the agmatine induced antinociception in neuropathic rats. Animals were subjected to sciatic nerve ligation for induction of neuropathic pain and observed the paw withdrawal latency in response to thermal hyperalgesia, cold allodynia and the mechanical hyperalgesia. Intrahippocampal (i.h.) as well as intraperitoneal (i.p.) administration of agmatine attenuated neuropathic pain in sciatic nerve ligated rats. Intrahippocampal administration of ¦Ò₁ agonist (+)-pentazocine or ¦Ò₂ agonist PB28 sensitized whereas, ¦Ò₁ antagonist BD1063 or ¦Ò₂ antagonist SM21 potentiated antinociceptive effect of agmatine. The behavioral effects correlated with hippocampal tumor necrosis factor-¦Á (TNF-¦Á) levels observed by western blot analysis. These results suggest that both the ¦Ò₁ and ¦Ò₂ receptor subunits within hippocampus play an important role in antinociceptive action of agmatine against neuropathic pain.