Mild, rapid and efficient metal-free synthesis of 2-aryl-4-aryloxyquinolines via direct C_sp²O bond formation by using diaryliodonium salts

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• 作者：Pradip D. Nahide ; Cé ; sar R. Solorio-Alvarado ; ^{csolorio@ugto.mx}
• 关键词：2-Aryl-4-aryloxyquinolines ; Iodonium salts ; Direct Csp2O bond formation ; Ligand- and metal-free reactions ; Non-toxic reactions
• 刊名：Tetrahedron Letters
• 出版年：2017
• 出版时间：25 January 2017
• 年：2017
• 卷：58
• 期：4
• 页码：279-284
• 全文大小：1460 K
• 卷排序：58

文摘

The first general method for synthesizing in one-pot the pharmacophore 2-aryl-4-aryloxyquinolines. A metal- and ligand-free procedure for the formation of a CO bond yielding functionalized quinolines. A totally, regio- and chemoselective O-arylation procedure for the functionalization of quinolines. The use of non symmetrical bisaryliodonium salts expending only PhI as organic byproduct.