Design and synthesis of fused tetrahydroisoquinoline-iminoimidazolines
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- 作者：Valeria Moas-Hé ; loirea ; b ; valeria.heloire-2@univ-lille2.fr" class="auth_mail" title="E-mail the corresponding author ; Nicolas Renaulta ; b ; nicolas.renault-3@univ-lille2.fr" class="auth_mail" title="E-mail the corresponding author ; Vania Batalhac ; vanialnbatalha@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Angela Rincon Ariase ; ararias@quim.ucm.es" class="auth_mail" title="E-mail the corresponding author ; Mathieu Marchivied ; mathieu.marchivie@icmcb.cnrs.fr" class="auth_mail" title="E-mail the corresponding author ; Said Yousa ; e ; said.yous@univ-lille2.fr" class="auth_mail" title="E-mail the corresponding author ; Noé ; mie Deguinea ; Luc Bué ; ea ; e ; luc.buee@inserm.fr" class="auth_mail" title="E-mail the corresponding author ; Philippe Chavattea ; f ; philippe.chavatte@univ-lille2.fr" class="auth_mail" title="E-mail the corresponding author ; David Bluma ; e ; david.blum@inserm.fr" class="auth_mail" title="E-mail the corresponding author ; Luisa Lopesc ; lvlopes@medicina.ulisboa.pt" class="auth_mail" title="E-mail the corresponding author ; Patricia Melnyka ; e ; patricia.melnyk@univ-lille2.fr" class="auth_mail" title="E-mail the corresponding author ; Laurence Agouridasa ; e ; laurence.agouridas@univ-lille2.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Guanidines ; A2A receptor ; Privileged structure ; Iminoimidazoline
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2015
- 出版时间：1 December 2015
- 年：2015
- 卷：106
- 期：Complete
- 页码：15-25
- 全文大小：1411 K
文摘
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Cyclic guanidines are proposed as a new privileged structure.
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Tic-guanidines were obtained in a 5-steps enantiopure original synthesis.
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Tic-guanidines were easily obtained from commercially available amino acids.