Proanthocyanidins from Chinese bayberry (Myrica rubra Sieb. et Zucc.) leaves regulate lipid metabolism and glucose consumption by activating AMPK pathway in HepG2 cells
BLPs reduced the activity of pancreatic lipase. SPBLPs and UDBLPs significantly activated AMPK in dose dependent manner. SPBLPs and UDBLPs reduced triglycerides synthesis by phosphorylating ACC. SPBLPs and UDBLPs reduced sterols biosynthesis by mainly inhibiting SREBP-1. SPBLPs promoted glucose consumption in HepG2 cells.