Platelet rich plasma in ocular surface

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• 作者：A.C. Riestra^a ; ^{ana.riestra@fio.as" class="auth_mail" title="E-mail the corresponding author} ; J.M. Alonso-Herreros^b ; J. Merayo-Lloves^a
• 关键词：Platelet rich plasma ; Plasma rich in growth factors ; Blood products ; Ocular surface ; Cornea
• 刊名：Archivos de la Sociedad Española de Oftalmología (English Edition)
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：91
• 期：10
• 页码：475-490
• 全文大小：969 K

文摘

The use of platelet-rich preparations has experienced a significant increase in recent years due to its role in tissue-repair and regeneration. The aim of this study is to examine the available evidence regarding the application of plasma rich in growth factors, and its variations, on the ocular surface. A review is also presented on the effects of platelet-derived growth factors, the implications of the preparation methods, and the existing literature on the safety and efficacy of these therapies in ocular surface diseases. Despite the widespread use of platelet preparations there is no consensus on the most appropriate preparation method, and growth factors concentration vary with different systems. These preparations have been used in the treatment of ocular surface diseases, such as dry eye or persistent epithelial defects, among others, with good safety and efficacy profiles, but further studies are needed to compare to the currently available alternatives.