Clinicopathological and immunohistochemical analysis of six cases of gastric globoid dysplasia

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• 作者：Leonardo Saú ; l Lino-Silva^a ; ^{saul.lino.sil@gmail.com} ; Rosa Ang&#233 ; lica Salcedo-Herná ; ndez^b ; Ernesto Molina-Frí ; as^b ; Roberto Herrera-Goepfert^a ; Alejandro Padilla-Rosciano^b
• 关键词：Gastric cancer ; Early carcinoma ; Signet ring ; Diffuse carcinoma ; Dysplasia ; Cancer
• 刊名：Revista Espa?ola de Patolog¨ªa
• 出版年：2013
• 出版时间：January-March, 2013
• 年：2013
• 卷：46
• 期：1
• 页码：26-32
• 全文大小：2456 K

文摘

Background

The pre-invasive lesions of Lauren's intestinal type of gastric cancer are well recognized but those of signet ring cell carcinoma (SRCC) have not been studied in detail. The putative precursor lesion of SRCC is poorly and ambiguously described as ¡®tubule neck dysplasia? ¡°non-metaplastic dysplasia?or ¡°globoid dysplasia?(GD). We describe 6 six cases of GD with an extensive immunohistochemical profile that has not been previously reported.

Material and method

Six cases of GD were retrieved from 659 cases of gastric biopsies positive for carcinoma (1 % ). Their clinical, morphological, and immunohistochemical features were analyzed.

Results

The male to female ratio was 1:2, the median age was 62.3 years (range 53-83 years), two cases were in clinical stage I, 2 cases in stage III and two cases in stage IV. After a follow-up of an average of 16 months (range 10-24 months), one patient had died from the neoplastic disease, 3 are alive but with disease and the remaining 2 are alive and disease-free. The immunohistochemical profile of GD is MUC5AC (+), Ki-67(+), p53+, p27(+),p16(+); MUC6(?, Na⁺K⁺ ATPasa (? and E-cadherin with reduced intensity.

Conclusion

Correct recognition of GD enables new and larger case studies, better clinical evaluation, longer follow-up and better characterization of genetic abnormalities. Thus, the study of more cases of GD is clearly beneficial.