Immune malfunction in the GPR39 zinc receptor of knockout mice: Its relationship to depressive disorder
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- 作者：Katarzyna Młynieca ; katarzyna.mlyniec@uj.edu.pl" class="auth_mail" title="E-mail the corresponding author ; Ewa Trojanb ; Joanna Ślusarczykb ; Katarzyna Głombikb ; Agnieszka Basta-Kaimb ; Bogusława Budziszewskab ; c ; Jakub Skrzeszewskid ; Agata Siweka ; Birgitte Holste ; Gabriel Nowaka ; b
- 关键词：GPR39 ; Zinc ; Proliferation ; Immune system ; Depression
- 刊名：Journal of Neuroimmunology
- 出版年：2016
- 出版时间：15 February 2016
- 年：2016
- 卷：291
- 期：Complete
- 页码：11-17
- 全文大小：567 K
文摘
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GPR39 KO mice show depressive-like behavior.
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GPR39 KO show mice reduced cell viability and reduced proliferative response of splenocytes.
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Increased IL-6 production of splenocytes after ConA stimulation in GPR39 KO is observed.
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GPR39 KO mice show decreased IL-1b and IL-6 release after LPS stimulation.
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GPR39 receptor plays an important role in proliferation and cytokines release