Protective role of peroxisome proliferator-activated receptor 尾/未 in acute lung injury induced by prolonged hyperbaric hyperoxia in rats
详细信息 查看全文
- 作者：Xiao-Chen Bao ; Yi-Qun Fang ; zhouqybb@gmail.com" class="auth_mail ; Pu You ; Shi Zhang ; Jun Ma
- 关键词：Pulmonary oxygen toxicity ; Peroxidase proliferator-activated receptor ; Inflammation ; Apoptosis
- 刊名：Respiratory Physiology & Neurobiology
- 出版年：1 August 2014
- 年：2014
- 卷：199
- 期：Complete
- 页码：9-18
- 全文大小：2653 K
文摘
- •
PPAR-尾/未 activation has a protective role against lung injury induced by HBO2.
- •
GW0742 decreases inflammatory mediators and apoptosis in lungs after HBO2 exposure.
- •
GW0742 elevates antioxidant enzyme activities after HBO2 exposure.
- •
GW0742 reduces NF-魏B activation and ERK1/2 phosphorylation after HBO2 exposure.