The Mitotic Checkpoint Complex Requires an Evolutionary Conserved Cassette to Bind and Inhibit Active APC/C

详细信息    查看全文

• 作者：Barbara Di Fiore¹ ; Claudia Wurzenberger¹ ; Norman E. Davey² ; Jonathon Pines¹ ; ³ ; ⁴ ; ^{jon.pines@icr.ac.uk}
• 关键词：mitosis ; checkpoint ; Spindle Assembly Checkpoint ; Anaphase Promoting Complex ; Cyclosome ; ABBA motif ; BubR1 ; Cdc20
• 刊名：Molecular Cell
• 出版年：2016
• 出版时间：15 December 2016
• 年：2016
• 卷：64
• 期：6
• 页码：1144-1153
• 全文大小：2918 K
• 卷排序：64

文摘

The N-terminal half of BubR1 contains two ABBA motifs that bind Cdc20 The motifs are required for the MCC to bind and inhibit active APC/C-Cdc20 These ABBA motifs are essential for the spindle assembly checkpoint The ABBA motifs flank a KEN box to form a cassette highly conserved in evolution