Propoxylation of cationic polymers provides a novel approach to controllable modulation of their cellular toxicity and interaction with nucleic acids
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- 作者：Vesta D. Shevchenko ; Diana V. Salakhieva ; Abdulla A. Yergeshov ; Yuriy V. Badeev ; Yurii G. Shtyrlin ; Timur I. Abdullin ; tabdulli@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cationic polymers ; Polyethyleneimine ; Propoxylation ; Biocompatibility ; Cellular toxicity ; Gene delivery
- 刊名：Materials Science & Engineering C
- 出版年：2016
- 出版时间：1 December 2016
- 年：2016
- 卷：69
- 期：Complete
- 页码：60-67
- 全文大小：679 K
文摘
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New propoxylated PEIs with different PO / NH molar ratio were synthesized
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Relationships between propoxylation degree of PEI and its interaction with cell membrane and DNA were established
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Propoxylation at 0.75 PO / NH ratio attenuates PEI cytotoxicity while preserves its DNA protection and transfection activity
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Propoxylation of cationic centers provides a balance between cytotoxicity and nucleic acid delivery of polymers