New propoxylated PEIs with different PO / NH molar ratio were synthesized
Relationships between propoxylation degree of PEI and its interaction with cell membrane and DNA were established
Propoxylation at 0.75 PO / NH ratio attenuates PEI cytotoxicity while preserves its DNA protection and transfection activity
Propoxylation of cationic centers provides a balance between cytotoxicity and nucleic acid delivery of polymers