Transcriptomic analyses of genes and tissues in inherited sensory neuropathies
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- 作者：Matthew R. Sapio ; Samridhi C. Goswami ; Jacklyn R. Gross ; Andrew J. Mannes ; Michael J. Iadarola ; miadarol@cc.nih.gov" class="auth_mail" title="E-mail the corresponding author
- 关键词：Pain ; Proprioception ; Charcot Marie Tooth ; Neuropathy ; Pain channelopathy ; Transcriptomics ; Schwann cells ; Gene expression ; Glia ; RNA-Seq ; Dorsal root ganglion ; Spinal cord ; Sodium channels ; TRPV1 ; TRPA1 ; Inherited peripheral neuropathy ; HSAN ; Sciatic nerve ; Adipocytes ; Myelin protein zero
- 刊名：Experimental Neurology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：283
- 期：part_PA
- 页码：375-395
- 全文大小：3625 K
文摘
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Transcriptomes of dorsal root ganglia and sciatic nerve are defined and compared.
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The body-wide expression patterns of known peripheral neuropathy genes are examined.
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Genes enriched in sensory neurons or Schwann cells are identified.
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Inherited sensory neuropathies are subdivided based on expression of the mutated gene.
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A new data-based conceptual framework for understanding these disorders is proposed.