Only few compounds were found to be active against the MDR strain of A. baumannii

Colistin is an amphipatic peptide antibiotic that can be considered a prototype membrane-perturbing agent.

The permeabilizing effect of colistin on the A. baumannii outer membrane may facilitate the entry of glycopeptide and lipopeptide molecules, which are usually excluded due to their size, resulting in an improvement patient outcomes in severe infections due to multiresistant microorganisms such as A. baumannii.