Effect of hyperglycemia on the number of CD117+ progenitor cells and their differentiation toward endothelial progenitor cells in young and old ages
详细信息 查看全文
- 作者：Elisa Pierpaoli ; Raffaella Moresi ; Fiorenza Orlando ; Marco Malavolta ; Mauro Provinciali ; m.provinciali@inrca.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：CD117+ progenitor cells ; Diabetes ; Aging ; Mouse
- 刊名：Mechanisms of Ageing and Development
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：159
- 期：Complete
- 页码：31-36
- 全文大小：699 K
文摘
- •
The effect of both aging and diabetes on the number and function of EPCs is proposed.
- •
Diabetes reduces the number of EPCs in bone marrow both in young and old mice.
- •
Diabetes induces functional defects of EPCs mainly in young than in old mice.
- •
Diabetes may represent an example of accelerated aging.