Blood pressure variability and stroke outcome in patients with internal carotid artery occlusion

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• 作者：Laura Buratti^a ; Claudia Cagnetti^a ; Clotilde Balucani^a ; ^b ; Giovanna Viticchi^a ; Lorenzo Falsetti^c ; Simona Luzzi^a ; Simona Lattanzi^a ; Leandro Provinciali^a ; Mauro Silvestrini^a ; ^{m.silvestrini@univpm.it" class="auth_mail}
• 关键词：Blood pressure ; Carotid stenosis ; Ischemic stroke ; Hypertension ; Treatment ; Risk factors
• 刊名：Journal of the Neurological Sciences
• 出版年：15 April, 2014
• 年：2014
• 卷：339
• 期：1-2
• 页码：164-168
• 全文大小：230 K

文摘

Purpose

The aim of this study was to evaluate the relationship between arterial blood pressure (BP) variability during the acute phase and the 3-month outcome in ischemic stroke patients with internal carotid artery (ICA) occlusion.

Methods

At least 10 BP measurements during the first 48 h after stroke onset were obtained in 89 patients with ICA occlusion. BP profile was described using various parameters: average of recordings, maximum (max), minimum (min), difference between max and min (max 鈭?#xA0;min), standard deviation (SD) and coefficient of variation (CV) for both systolic and diastolic BP. Outcome at 3 months was defined using the modified Rankin Scale (mRS) score corrected for baseline stroke severity.

Results

Fifty-five patients had a good and 34 a poor outcome. Max values, max 鈭?#xA0;min, SD and CV of both systolic and diastolic BP resulted significantly higher in patients with poor outcome compared to those with good outcome (p < 0.05, multivariate adjusted model).

Conclusions

In a cohort of acute ischemic stroke patients with ipsilateral ICA occlusion BP variability, assessed in the acute phase, was associated with poor clinical outcome. These preliminary exploratory findings are worthy of further study to be conducted to confirm or confute the role of BP variability in predicting stroke outcome. In order to obtain more comprehensive information, it would also be appropriate to consider the possibility of acquiring data related to the pathophysiology of stroke and to cerebral hemodynamic changes.