Introducing a cleavable signal peptide enhances the packaging efficiency of lentiviral vectors pseudotyped with Japanese encephalitis virus envelope proteins

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• 作者：Hanyang Liu^a ; ¹ ; Rui Wu^a ; ¹ ; Lei Yuan^a ; Geng Tian^a ; Xiaobo Huang^a ; ^b ; Yiping Wen^a ; ^b ; Xiaoping Ma^a ; Yong Huang^a ; Qigui Yan^a ; Qin Zhao^a ; Sanjie Cao^a ; ^b ; ^{csanjie@gmail.com} ; Xintian Wen^a ; ^b ; ^{xintian3211@126.com}
• 关键词：Signal peptide ; Packaging efficiency ; Japanese encephalitis virus ; Pseudotyped virus
• 刊名：Virus Research
• 出版年：2017
• 出版时间：2 February 2017
• 年：2017
• 卷：229
• 期：Complete
• 页码：9-16
• 全文大小：1473 K
• 卷排序：229

文摘

The signal peptide gene of VSV G protein was introduced into JEV envelope expression vector. JEV E protein and HIV p24 were present in the same particles of the three pseudotyped JEV-E based lentiviral vectors. Signal peptide enhanced packaging efficiency of pseudotyped JEV-E based lentiviral vector, and a strong signal peptide. Signal peptide does not influence the infectivity of pseudotyped JEV-E based lentiviral vectors.