Retinal gap junctions are involved in rhythmogenesis of neuronal activity at remote locations - Study on infra-slow oscillations in the rat olivary pretectal nucleus
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- 作者：Patrycja Orlowska-Feuera ; &dagger ; ; Jagoda S. Jeczmien-Lazura ; &dagger ; ; Hanna J. Szkudlarekb ; szkudlarek.edu@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Marian H. Lewandowskia ; marian.lewandowski@uj.edu.pl" class="auth_mail" title="E-mail the corresponding author
- 关键词：2-APB ; 2-aminoethoxydiphenylborane ; CBX ; carbenoxolone ; ChSB ; Chicago Sky Blue ; Cx ; connexins ; EB ; extraburst ; FFT ; Fast Fourier Transform ; GJs ; gap junctions ; IB ; intraburst ; ipRGCs ; intrinsically photosensitive retinal ganglion cells ; LED ; light emitting diode ; MFA ; meclofenamic acid ; OPN ; olivary pretectal nucleus ; PBS ; buffered physiological saline ; PSTHs ; peri-stimulus time histograms ; RGCs ; retinal ganglion cells
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：17 December 2016
- 年：2016
- 卷：339
- 期：Complete
- 页码：150-161
- 全文大小：1795 K
文摘
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Pharmacological blockade of retinal gap junctions with CBX or MFA leads to abolition of infra-slow oscillations in the OPN.
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The effect of CBX on light-induced responses of the OPN oscillatory cells is GJs independent.
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Retinal synchrony might be crucial for the expression of the infra-slow rhythm at remote locations.