Angiopoietin-like protein 8 (ANGPTL8) in pregnancy: a brown adipose tissue-derived endocrine factor with a potential role in fetal growth

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• 作者：Bruno Martinez-Perez^a ; Miriam Ejarque^a ; ^b ; Cristina Gutierrez^a ; ^b ; Catalina Nuñ ; ez-Roa^a ; ^b ; Kelly Roche^a ; ^b ; Rocio Vila-Bedmar^c ; ^d ; Mó ; nica Ballesteros^a ; Ibon Redondo-Angulo^e ; ^f ; Anna Planavila^e ; ^f ; Francesc Villarroya^e ; ^f ; Joan Vendrell^a ; ^b ; Sonia Ferná ; ndez-Veledo^a ; ^b ; ^{sonia.fernandezveledo@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Ana Megí ; a^a ; ^b ; ^{ana.megia@gmail.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：ANGPTL8 ; angiopoietin-like protein 8 ; GDM ; gestational diabetes mellitus ; WAT ; white adipose tissue ; BAT ; brown adipose tissue ; OGTT ; oral glucose tolerance test ; BMI ; body mass index ; LGA ; large for gestational age ; AGA ; adequate for gestational age ; SGA ; small for gestational age ; SSF ; sum of 3 skinfolds ; HOMA-IR ; insulin resistance homeostatic model assessment ; HOMA-B ; beta cell function&mdash ; homeostatic model assessment ; hWA ; human white adipocytes ; hBA ; human brown adipocytes ; mBA ; murine
• 刊名：Translational Research
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：178
• 期：Complete
• 页码：1-12
• 全文大小：736 K

文摘

Angiopoietin-like protein 8 (ANGPTL8), a protein implicated in lipid and glucose homeostasis, is present only in mammals, suggesting that it is involved in processes unique to these vertebrates such as pregnancy and homeothermy. We explored the role of ANGPTL8 in maternal-fetal crosstalk and its relationship with newborn adiposity. In a longitudinal analysis of healthy pregnant women, ANGPTL8 levels decreased progressively during pregnancy although remained higher than levels in the postpartum period. In a cross-sectional observational study of women with or without gestational diabetes mellitus (GDM), and their offspring, ANGPTL8 levels were higher in venous cord blood than those in maternal blood and were significantly lower in GDM patients than those in healthy women. Infants small for gestational age and with low-fat mass had the highest ANGPTL8 cord blood levels. Studies in vitro revealed that ANGPTL8 was secreted by brown adipocytes and its expression was increased in experimental models of white-to-brown fat conversion. In addition, ANGPTL8 induced the expression of markers of brown adipocytes. The high levels of ANGPTL8 found in fetal life together with its relationship with newborn adiposity and brown adipose tissue point to ANGPTL8 as a potential new player in the modulation of the thermogenic machinery during the fetal-neonatal transition.