Success and failure of biological treatment in systemic lupus erythematosus: A critical analysis
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- 作者：Mariele Gatto ; Francesca Saccon ; Margherita Zen ; Silvano Bettio ; Luca Iaccarino ; Leonardo Punzi ; Andrea Doria ; adoria@unipd.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：Outcome measure ; Biologics ; Anti-CD20 ; BLyS ; Registries ; Lupus nephritis
- 刊名：Journal of Autoimmunity
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：74
- 期：Complete
- 页码：94-105
- 全文大小：759 K
文摘
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Major organ damage in SLE is caused by long-standing immunesuppressive therapy.
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Several trials have failed in SLE due to disease heterogeneity and study design.
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Rituximab is effective in refractory manifestations, especially LN.
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B cells are still promising targets in SLE therapy.
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Combination strategies are required to spare steroids and improve disease outcome.