Kidney Transplantation in Hereditary Coproporphyria Using Tacrolimus and Mycophenolate Mofetil: A Case Report

详细信息    查看全文

• 作者：G. Telkes ; A. Pusztai ; K. F枚ldes ; R.M. Langer
• 刊名：Transplantation Proceedings
• 出版年：December, 2013
• 年：2013
• 卷：45
• 期：10
• 页码：3703-3704
• 全文大小：236 K

文摘

Background

The porphyrias are a group of disorders of the heme biosynthesis pathway that may present with acute life-threatening attacks, commonly exacerbated by a wide variety of medications. Many newer immunosuppressive medications, which are in use following kidney transplantation, have not been fully explored in acute porphyrias.

Case report

A 53-year-old woman received a kidney from a deceased donor, after being on hemodialysis for 4 years. Hereditary coproporphyria was diagnosed at age 19 years. We administered tacrolimus, mycophenolate mofetil and steroid immunosuppression. In the immediate post-transplant periods she displayed abdominal pain and transient uroporphyrin elevation in parallel with slightly elevated (15 ng/mL) tacrolimus concentrations. As the target tacrolimus level was achieved, these findings disappeared.

Conclusions

Tacrolimus, mycophenolate- mofetil, and steroid therapy for hereditery coproporphyri was safe, in the long term.