Simultaneous HPLC assay for pretomanid (PA-824), moxifloxacin and pyrazinamide in an inhaler formulation for drug-resistant tuberculosis

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• 作者：Mohammad A.M. Momin ; Sim J. Thien ; Woravimol Krittaphol ; Shyamal C. Das ; ^{shyamal.das@otago.ac.nz}
• 关键词：Pretomanid (PA-824) ; Moxifloxacin ; Pyrazinamide ; HPLC ; Spray-dried powder for inhalation ; l-leucine
• 刊名：Journal of Pharmaceutical and Biomedical Analysis
• 出版年：2017
• 出版时间：20 February 2017
• 年：2017
• 卷：135
• 期：Complete
• 页码：133-139
• 全文大小：923 K
• 卷排序：135

文摘

Development of a RP-HPLC method for the simultaneous quantitation of pretomanid (PA-824), moxifloxacin and pyrazinamide. Simple, accurate, precise and sensitive method to analyze three drugs. Freedom from interference by l-leucine. Successful evaluation of content uniformity of a triple combination spray-dried powder.