Major dorsoventral differences in the modulation of the local CA1 hippocampal network by NMDA, mGlu5, adenosine A2A and cannabinoid CB1 receptors
详细信息 查看全文
- 作者：S. Kouvaros ; C. Papatheodoropoulos ; cepapath@upatras.gr" class="auth_mail" title="E-mail the corresponding author
- 关键词：A2AR ; adenosine A2A receptor ; AM 281 ; 1-(2 ; 4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-4-morpholinyl-1H-pyrazole-3-carboxamide ; CB1R ; cannabinoid CB1 receptor ; CGS ; 4-[2-[[6-amino-9-(N-ethyl-β-D-ribofuranuronamidosyl)-9H-purin-2-yl]amino]ethyl]benzenepropanoic acid hydrochloride ; CHPG ; (RS)-2-chloro-5-hydroxyphenylglycine sodium salt ; CPP ; 3-((R)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid ; DH ; dorsal hippocampus ; DMSO ; dimethyl-sulfoxide ; DPCPX ; 8-cyclopentyl-1 ; 3-dipropylxanthine ; EPSP
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：11 March 2016
- 年：2016
- 卷：317
- 期：Complete
- 页码：47-64
- 全文大小：1668 K
文摘
- 5">
- •
5">Activation of NMDAR reduces transmission more in VH than in DH.
- •
Activation of NMDAR enhances excitability and reduces inhibition in DH but not VH.
- •
5">The mGluR5 potentiates the synergistic effects of NMDAR in DH but not VH slices.
- •
The A2AR exerts permissive role on mGluR5–NMDAR synergy in DH only.
- •
5">CB1R participates in mediating the synergistic effects of mGluR5–NMDAR.