Tetracyanoethylene as a mediator and building block in synthesis of 5-substituted amino-1,3,4-thiadiazolyl-1H-pyrazole derivatives

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• 作者：Alaa A. Hassan^a ; ^{alaahassan2001@mu.edu.eg" class="auth_mail" title="E-mail the corresponding author} ; Shaaban K. Mohamed^a ; ^b ; Fathy F. Abdel-Latif^a ; Sara M. Mostafa^a ; Joel T. Mague^c ; Mehmet Akkurt^d ; Mohamed Abdel-Aziz^e
• 关键词：Thiocarbonohydrazides ; Tetracyanoethylene ; 5-Substituted amino-1 ; 3 ; 4-thiadiazol-yl-1H-pyrazole
• 刊名：Tetrahedron Letters
• 出版年：2016
• 出版时间：20 January 2016
• 年：2016
• 卷：57
• 期：3
• 页码：345-347
• 全文大小：460 K

文摘

The conversion of thiocarbonohydrazides to 5-substituted amino-1,3,4-thiadiazolyl-1H-pyrazoles in one-step was achieved via the reaction with tetracyanoethylene (TCNE). In this conversion, TCNE is used as a mediator and/or a building block. The product was conclusively confirmed by spectroscopic data and single crystal X-ray structural analysis.