The dual-acting H3 receptor antagonist and AChE inhibitor UW-MD-71 dose-dependently enhances memory retrieval and reverses dizocilpine-induced memory impairment in rats
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- 作者：Nadia Khana ; Ali Saada ; Syed M. Nurulaina ; Fouad H. Darrasb ; Michael Deckerb ; c ; Bassem Sadeka ; bassem.sadek@uaeu.ac.ae" class="auth_mail" title="E-mail the corresponding author
- 关键词：Histamine H3 receptor ; Acetylcholinesterase ; Dual-acting ligand ; Learning ; Memory ; Inhibitory avoidance test ; Pyrilamine ; Zolantidine.
- 刊名：Behavioural Brain Research
- 出版年：2016
- 出版时间：15 January 2016
- 年：2016
- 卷：297
- 期：Complete
- 页码：155-164
- 全文大小：2292 K
文摘
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The effects of UW-MD-71, a highly selective and dual-acting H3R antagonist and AChEI, on acquisition, consolidation, retrieval, and dizocilpine-induced amnesia were tested.
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Acute UW-MD-71 administration improved retrieval dose-dependently and ameliorated dizocilpine-induced amnesia.
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The results are the first demonstration for in vivo effectiveness of such a dual-acting ligand and shed light on their mode of action in mediating procognitive effects.