Anticonvulsant and procognitive properties of the non-imidazole histamine H3 receptor antagonist DL77 in male adult rats
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- 作者：Bassem Sadeka ; bassem.sadek@uaeu.ac.ae" class="auth_mail" title="E-mail the corresponding author ; Ali Saada ; Dhanasekaran Subramaniana ; Mohamed Shafiullaha ; Dorota Łażewskab ; Katarzyna Kieć-Kononowiczcb
- 关键词：Histamine H3 receptor ; Epilepsy ; Anticonvulsant ; Learning ; Memory ; Passive avoidance test ; Pyrilamine ; R-(α)-methyl-histamine
- 刊名：Neuropharmacology
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：106
- 期：Complete
- 页码：46-55
- 全文大小：1297 K
文摘
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The effects of the H3R antagonist DL77 in different epilepsy and memory models were tested.
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Acute DL77 administration provided anticonvulsant and memory-enhancing effects.
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The results shed light on the potential therapeutic importance of H3Rs in epilepsy and memory.