Secondary Necrosis: Accidental No More

详细信息    查看全文

• 作者：Lorenzo Galluzzi¹ ; ² ; ³ ; ⁴ ; ⁵ ; ⁶ ; ^{deadoc@vodafone.it} ; Guido Kroemer² ; ³ ; ⁴ ; ⁵ ; ⁷ ; ⁸ ; ⁹
• 关键词：caspases ; danger signaling ; DFNA5 ; GSDMD ; necroptosis ; pyroptosis
• 刊名：Trends in Cancer
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：3
• 期：1
• 页码：1-2
• 全文大小：477 K
• 卷排序：3

文摘

Recent data demonstrate that secondary necrosis is not an accidental epiphenomenon of apoptosis, but a finely regulated process with prominent pathophysiological and therapeutic implications. The molecular machinery that controls secondary necrosis stands out as a promising target for the development of novel drugs that may increase the immunogenicity of cancer cells succumbing to treatment.